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Viagra inhibits an enzyme called phosphodiesterase-5 (PDE5) which destroys the cGMP. Thus, Viagra prevents the destruction of cGMP and allows cGMP to accumulate and persist longer. The longer cGMP persists, the more prolonged the engorgement of the penis. The FDA approved Viagra in March 1998. viagra 25 mg how long does it last The primary exposure was sildenafil use for ED. In 2000, participants were queried as to whether they had undergone surgery or treatment to correct problems with erections during the past 3 months, including sildenafil, shots or penile injection, vacuum suction, alprostadil, and other treatments, and whether they had ever received any treatment for ED before, including sildenafil. However, no information on the dose or frequency of sildenafil was collected.Ordering Viagra online at us is simple, safe, and secure. Even if you don’t have an existing prescription, you can purchase Viagra by making use of our free medical consultation. Simply fill out our online medical questionnaire and a doctor will determine if you’re healthy enough to take Viagra. No physical examination is required.

However, some men have persistent, or recurring, ED. It can occur at any age, but becomes more common with increasing age. About half of men between the ages of 40 and 70 have ED. About 7 in 10 men aged 70 and above have ED.

cheap cialis canadian Carcinogenesis, Mutagenesis, Impairment of FertilityPhysicians should discuss with patients the appropriate action in the event that they experience anginal chest pain requiring nitroglycerin following intake of Cialis. In such a patient, who has taken Cialis, where nitrate administration is deemed medically necessary for a life-threatening situation, at least 48 hours should have elapsed after the last dose of Cialis before nitrate administration is considered. In such circumstances, nitrates should still only be administered under close medical supervision with appropriate hemodynamic monitoring. Therefore, patients who experience anginal chest pain after taking Cialis should seek immediate medical attention [see Contraindications (4.1) and Warnings and Precautions (5.1)].

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