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Table 6: Mean QT and QTc changes in msec (90% CI) from baseline relative to placebo at 1 hour post-dose with different methodologies to correct for the effect of heart rate. Drug/Dose QT Uncorrected natural viagra Cardiovascular: palpitation, tachycardia, angina pectoris, myocardial infarction, ventricular tachyarrhythmias, hypotension

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Viagra (sildenafil) works by inhibiting the chemical phosphodiesterase, which leads to an increase in the effect of nitric oxide. Nitric oxide allows the smooth muscles inside the penis to relax, promoting more blood flow to the area during sexual arousal or stimulation. Nitric oxide also opens the blood vessels throughout the body, which can cause decreased blood pressure. This decrease in blood pressure may increase the effects of blood-pressure lowering drugs, especially alpha-blockers, such as terazosin (Hytrin), doxazosin (Cardura), and prazosin (Minipress). Patients with cardiovascular disease could have additional side effects from Viagra, especially in combination with sexual activity. Other common side effects of Viagra include warmth or redness in your face, neck, or chest; stuffy nose; headache; upset stomach; and back pain. More serious, but less frequent side effects include prolonged erection lasting more than 4 hours, vision changes, and loss of hearing. If these occur, you should contact your health care provider. Results in General ED Population in Trials Outside the US — The 5 primary efficacy and safety studies conducted in the general ED population outside the US included 1112 patients, with a mean age of 59 years (range 21 to 82 years). The population was 76% White, 1% Black, 3% Hispanic, and 20% of other ethnicities, and included patients with ED of various severities, etiologies (organic, psychogenic, mixed), and with multiple co-morbid conditions, including diabetes mellitus, hypertension, and other cardiovascular disease. Most (90%) patients reported ED of at least 1-year duration. In these 5 trials, Cialis 5, 10, and 20 mg showed clinically meaningful and statistically significant improvements in all 3 primary efficacy variables (see Tables 12, 13 and 14). The treatment effect of Cialis did not diminish over time. cialis duration PlaceboThere have been postmarketing reports of bleeding events in patients who have taken Viagra. A causal relationship between Viagra and these events has not been established. In humans, Viagra has no effect on bleeding time when taken alone or with aspirin. However, in vitro studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside (a nitric oxide donor). In addition, the combination of heparin and Viagra had an additive effect on bleeding time in the anesthetized rabbit, but this interaction has not been studied in humans. Adcirca?Of the total number of subjects in clinical studies of Viagra, 18% were 65 years and older, while 2% were 75 years and older. No overall differences in safety or efficacy were observed between older (≥ 65 years of age) and younger (< 65 years of age) subjects.

Hepatic Impairment: For patients with moderate hepatic impairment (Child-Pugh B), a starting dose of 5 mg LEVITRA is recommended. The maximum dose in patients with moderate hepatic impairment should not exceed 10 mg. side effects of drugs Men who have had a heart attack or stroke within the past 6 months and those with certain medical conditions (e.g., uncontrolled high blood pressure, severe low blood pressure or liver disease, unstable angina) that make sexual activity inadvisable should not take Cialis. Dosages of the drug should be limited in patients with kidney or liver disorders.

Stop using sildenafil and call your doctor at once if you have a serious side effect such as: vision changes or sudden vision loss; or

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