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Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.9 users found this comment helpful. Did you? Yes No Report as inappropriate levitra 20mg tablets Cialis (PRN use)

In these cases, your doctor may decide that you need a higher dose.

dapsoneCaution is advised when PDE5 inhibitors are co-administered with alpha-blockers. PDE5 inhibitors, including Viagra, and alpha-adrenergic blocking agents are both vasodilators with blood pressure lowering effects. When vasodilators are used in combination, an additive effect on blood pressure may occur. In some patients, concomitant use of these two drug classes can lower blood pressure significantly [see Drug Interactions (7.2) and Clinical Pharmacology (12.2)] leading to symptomatic hypotension (e.g., dizziness, lightheadedness, fainting). how long does viagra take to work 48. Goldmeier D, Lamba H "Prolonged erections produced by dihydrocodeine and sildenafil." BMJ 324 (2002): 1555WHAT IMPORTANT INFORMATION SHOULD YOU KNOW ABOUT LEVITRA?

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CounsellingWhat tests may be done?

viagra 50 mg equivalent cialis Viagra is generally well tolerated, but you may experience some side effects. Minor side effects include headache, stomach upset, blurry vision, dizziness, light sensitivity, skin flushing, and rash. Some patients may experience rare side effects that are more serious, including loss of hearing, temporary blindness, and an erection that lasts more than 4 hours. If you experience any of these more serious side effects, seek medical attention immediately. swelling of the lips, tongue, or throatplz help meVascular disorders

Results in Studies to Determine the Optimal Use of Cialis — Several studies were conducted with the objective of determining the optimal use of Cialis in the treatment of ED. In one of these studies, the percentage of patients reporting successful erections within 30 minutes of dosing was determined. In this randomized, placebo-controlled, double-blinded trial, 223 patients were randomized to placebo, Cialis 10, or 20 mg. Using a stopwatch, patients recorded the time following dosing at which a successful erection was obtained. A successful erection was defined as at least 1 erection in 4 attempts that led to successful intercourse. At or prior to 30 minutes, 35% (26/74), 38% (28/74), and 52% (39/75) of patients in the placebo, 10-, and 20-mg groups, respectively, reported successful erections as defined above.