Metabolism — Tadalafil is predominantly metabolized by CYP3A4 to a catechol metabolite. The catechol metabolite undergoes extensive methylation and glucuronidation to form the methylcatechol and methylcatechol glucuronide conjugate, respectively. The major circulating metabolite is the methylcatechol glucuronide. Methylcatechol concentrations are less than 10% of glucuronide concentrations. In vitro data suggests that metabolites are not expected to be pharmacologically active at observed metabolite concentrations. how long does cialis last 10 mg Cialis
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The recommended starting dose of CIALIS for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.44. Gandhi JS "Sildenafil-associated NAION." Ophthalmology 110 (2003): 1860-1; author reply 1861 viagra 100 Initial dose: 50 mg orally once a day, as needed, 1 hour prior to sexual activity11. Arruda-Olson AM, Pellikka PA "Appropriate use of exercise testing prior to administration of drugs for treatment of erectile dysfunction." Herz 28 (2003): 291-7Cialis, on the other hand, was developed a few years later for the sole purpose of treating erectile dysfunction, and was approved in 2003. Unlike Viagra, it can be taken daily or “as-needed” within 36 hours of sex. Viagra works for roughly four hours and must be taken 30 to 60 minutes before sex, according to the drug’s website.EF Domain ScorePenile haemorrhage, Haematospermia
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Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].
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