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In the secondary analysis excluding those with major chronic diseases at baseline, 79 melanoma cases were identified among 14?912 participants. Recent sildenafil users had a significantly elevated risk of invasive melanoma (HR,?2.24; 95% CI, 1.05-4.78) (eTable 2 in the Supplement). Ever use of sildenafil was also associated with increased melanoma risk (HR.?2.77; 95% CI, 1.32-5.85).dry mouth
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