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CIALIS for Once Daily Use for Erectile Dysfunction and Benign Prostatic HyperplasiaHealthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil resulting in approximately 84% and 107% higher plasma AUC values of sildenafil and its active N-desmethyl metabolite, respectively, compared to those seen in healthy young volunteers (18–45 years) [see Clinical Pharmacology (12.3)]. Due to age-differences in plasma protein binding, the corresponding increase in the AUC of free (unbound) sildenafil and its active N-desmethyl metabolite were 45% and 57%, respectively [see Clinical Pharmacology (12.3)].
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a.) Typical Dosage RecommendationsSome additional subjects in both the tadalafil and placebo groups were categorized as outliers in the period beyond 24 hours.
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